李川昀 研究员
生物信息学与基因组医学研究组
北京大学 未来技术学院 研究员，博士生导师
电话：
E-mail：chuanyunli@pku.edu.cn
主要研究方向是以恒河猴为特色模型，探究“人之为人”的分子基础。
李川昀实验室结合生命、信息科学研究策略，以恒河猴为特色模型，探究“人之所以为人”的遗传基础，理解人类高级智能。实验室创建了国际知名的RhesusBase信息系统，解决了该领域多个瓶颈问题，将恒河猴升级为可支撑高分辨率机制与功能研究的特色模型。据此，准确鉴定人类新基因、新调控，提出多项新理论探究其演化规律，并阐明两例新基因在人脑特异性发育中的功能。相关工作担任通讯作者在Nature Ecology & Evolution、PNAS、Science Advances等发表论文21篇，新理论得到国际同行广泛认可，Science等发表多篇专评赞赏工作的科学意义。获国家优秀青年科学基金、青年拔尖人才等，获贝时璋青年生物物理学家奖等，指导的博士生获吴瑞奖。
Ding WQ, Li XS , Zhang J, Ji MJ , Zhang ML, Zhong XM, Cao Y, Liu XG, Li CQ, Xiao CF, Wang JX , Li T, Yu Q, Mo F, Zhang BY, Qi JH, Yang JC, Qi JT, Tian L, Xu XW, Peng Q, Zhou WZ, Liu ZJ, Fu AS, Zhang XQ, Zhang JJ, Sun YJ, Hu BY, An NA, Zhang L, Li CY. (2024) Adaptive functions of structural variants in human brain development.Sci. Adv., 10: eadl4600.
Ji MJ, Yu Q, Yang XZ, Yu XH, Wang JX, Xiao CF, An NA, Han CH, Li CY, Ding WQ. (2024) Long-range alternative splicing contributes to neoantigen specificity in glioblastoma. Brief. Bioinform., 25: bbae503.
Xiao CF, Mo F, Lu YF, Xiao Q, Yao C, Li T, Qi JH, Liu XG, Chen JY, Zhang L, Guo TN, Hu BY, An NA, Li CY. (2024) Reply to: Identification of old coding regions disproves the hominoid de novo status of genes. Nat. Ecol. Evol., 8: 1831-1834.
Liu XG, Xiao CF, Xu XW, Zhang J, Mo F, Chen JY, Delihas N, Zhang L, An NA, Li CY. (2024) Origin of functional de novo genes in humans from “hopeful monsters. WIREs RNA, 15: e1845.
Ding WQ, Li XS, Zhang J, Ji MJ, Zhang ML, Zhong XM, Cao Y, Li CQ, Liu XG, Xiao CF, Li T, Yu Q, Mo F,Zhang BY, Qi, JH Yang JC, Wang JX, Qi JT, Tian L, Xu XW, Peng Q, Zhou WZ,Liu ZJ, Fu AS, An NA, Zhang XQ, Zhang JJ, Hu BY, Sun YJ, Zhang L, Li CY. (2024) Adaptive structural variants encode human uniqueness in brain developments. Science Advances, in revision
Zhang J, Peng Q, Ma CC, Xiao CF, Li T, Liu XG, Zhou LK, Zhou WZ, Ding WQ, An NA, LiuY,Li CY. (2023) 6mA-Sniper: quantifying 6mA sites in eukaryotes at single-nucleotide resolution. Science Advances, 9: eadh7912.
Li XS, Xiao CF, Qi JT, Xue WZ, Xu XW, Mu ZL, Zhang J, Li CY, Ding WQ. (2023) STellaris: a web server for accurate spatial mapping of single cells based on spatial transcriptomics data. Nucleic Acids Research, 51: W560-W568.
Ma CC, Xue TL, Peng Q, Zhang J, Guan JL, Ding WQ, Li Y, Xia PX, Zhou LK, Zhao TY, Wang S, Quan L, Li CY, Liu Y. (2023) N6-Deoxyadenine methyltransferase modulates C. elegans immunity via dichotomous mechanisms. Cell Research, 33: 628-639.
Qi JH, Mo F, An NA, Mi TW, Wang JX, Qi JT, Li XS, Zhang BY, Xia LK, Lu YF, Sun GY, Wang XY, Li CY, Hu BY. (2023) A human-specific de novo protein promotes cortical expansion and folding. Advanced Science, 10: e2204140.
An NA, Zhang J, Mo F, Luan XK, Shen QS, Li XS, Li CQ, Tian L, Zhang BY, Qi JT, Ji MJ, Qi JH, Zhou WZ, Ding WQ, Zhang L, Chen JY, Shu SK, Hu BY, Li CY. (2023) Human-specific genes with an lncRNA origin encode unique human brain developmental functionality. Nature Ecology & Evolution, 7: 264-278.
Li YM, Shen QS, Peng Q, Ding WQ, Zhang J, Zhong XM, An NA, Ji MJ, Zhou WZ,Li CY. (2021) Polyadenylation-related isoform switching in human evolution revealed by full-length transcript structure. Briefings in Bioinformatics, 22: bbab157.
Shao LW, Peng Q, Dong MY, Gao KY, Li YM, Li Y, Li CY, Liu Y. (2020) Histone deacetylase HDA-1 modulates mitochondrial stress response and longevity. Nature Communications, 11: 4639.
安妮、刘笑歌、纪明君、肖淳夫、李婷、齐俊添、王佳欣、李春琼、杨书涵、徐欣蔚、姚超、谢依诺
