高歌 教授
计算基因组学研究组
北京大学 生物医学前沿创新中心/生命科学学院 教授，博士生导师
电话：
E-mail：gaog@mail.cbi.pku.edu.cn
1.组学大数据的整合与挖掘
2.长非编码RNA 、转录因子等重要转录调控因子的功能与演化
高歌实验室长期致力于开发新生物信息技术以精准解析细胞调控图谱，并探索其在重大慢性疾病精准诊疗中的应用。近年来于Nature Biotechnology、Nature Communications、Nucleic Acids Research等领域高影响力刊物、NeurIPS等人工智能领域顶会上发表通讯作者论文30余篇，累计他引逾万次，多次获评Clarivate/SCI全球高被引学者、Elsevier中国高被引学者等。近五年实验室自主开发的十余个生物信息学新算法软件及数据库获海内外有效访问15亿次，半数以上来自海外，跻身于国内自主开发最具国际影响力的生物信息技术行列，多项成果入选ESI Highly Cited (Top 1%)论文、中国生物信息学十大进展、中国生物信息学十大数据库、中国热点论文榜等。
Wang Y, Liang N, Gao G. (2024) Quantifying the regulatory potential of genetic variants via a hybrid sequence-oriented model with SVEN. Nat. Commun., 15: 10917.
Chen ZY, Wei L, Gao G. (2024) Foundation models for bioinformatics. Quant. Biol., 12: 339-344.
Liu X, Zhang XY, Kang YJ, Huang F, Liu S, Guo YX, Li YN, Yin CC, Liu ML, Han QM, Wang QW, Ye H, Yao HH, Li C, Li JH, Pingcuo WZ, Zhang Y, Su Y, Gao G, Li ZG, Sun XL. (2024) An autoantibody profile identified by human genome-wide protein arrays in rheumatoid arthritis. MedComm, 5: e679.
Xia CR, Cao ZJ, Tu XM, Gao G. (2023) Spatial-linked alignment tool (SLAT) for aligning heterogenous slices. Nat. Commun., 14: 7236.
Wen ZY, Kang YJ, Ke L, Yang DC, Gao G. (2023) Genome-wide identification of gene loss events suggests loss relics as a potential source of functional incRNAs in humans. Mol. Biol. Evol., 40: msad103.
Cao ZJ, Gao G. (2022) Multi-omics single-cell data integration and regulatory inference with graph-linked embedding. Nat. Biotechnol., 40: 1458-1466.
Tu XM, Cao ZJ, Xia CR, Mostafavi S, Gao G. (2022) Cross-Linked Unified Embedding for cross-modality representation learning. In 36th Conference on Neural Information Processing Systems (NeurIPS 2022).
Kang YJ, Li JY, Ke L, Jiang S, Yang DC, Hou M, Gao G. (2022) Quantitative model suggests both intrinsic and contextual features contribute to the transcript coding ability determination in cells. Brief Bioinform., 23: bbab483.
Cao ZJ, Wei L, Lu S, Yang DC, Gao G. (2020) Searching large-scale scRNA-seq databases via unbiased cell embedding with cell BLAST. Nat. Commun., 11: 3458.
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