Inflammasome assembly and gasdermin D biology in health and disease
Title: Inflammasome assembly and gasdermin D biology in health and disease
Speaker: Hao Wu, Ph.D.
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School
Program in Cellular and Molecular Medicine, Boston Children’s Hospital, Member of National Academy of Sciences
Time:2019-3-14, 10:00-11:30AM
Place: College of life sciences, Youcai Deng 101 room
Abstract：
My laboratory has been interested in using structural biology to address fundamental questions in immunological processes. In innate immunity, the important family of complexes, known as inflammasomes, activate inflammatory caspases to induce cytokine processing and pyroptotic cell death. In this presentation, I will focus on 1) assembly of inflammasomes 2) cellular localization of inflammasomes and 3) gasdermin D structure, function and inhibitor discovery.
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