曾虎 研究员
时空生物学研究组
北京大学 未来技术学院 研究员，博士生导师
电话：
E-mail：huzeng@pku.edu.cn
1. 开发时空多组学技术
2. 解析基因表达调控网络
3. 探究肿瘤和神经退行性疾病等重大疾病的致病机理
研究工作围绕“中心法则”，综合运用生物、化学、物理等多学科交叉，建立具有时间、空间和单细胞分辨率测序技术，并运用这些技术探究基因表达调控和疾病致病机理。具体包括：1）开发空间翻译组测序技术，揭示亚细胞定位、细胞周期、细胞类型和脑区特异的翻译调控；2）开发空间转录组与蛋白质共检测技术，绘制阿尔茨海默症小鼠脑组织病理图谱；3）开发时空转录组测序技术，在亚细胞尺度揭示RNA动力学图谱。
Zeng H, Huang J, Ren J, Wang CK, Tang Z, Zhou H, Zhou Y, Shi H, Aditham A, Sui X, Chen H, Lo JA, Wang X. (2023) Spatially Resolved single-cell translatomics at molecular resolution. Science, 380: eadd3067.
Ren J, Zhou H, Zeng H, Wang CK, Huang J, Qiu X, Sui X, Li Q, Wu X, Lin Z, Lo JA, Maher K, He Y, Tang X, Lam J, Chen H, Li B, Fisher DE, Liu J, Wang X. (2023) Spatiotemporally resolved transcriptomics reveals the subcellular RNA kinetic landscape. Nat. Methods, 20: 695-705.
Zeng H, Huang J, Zhou H, Meilandt WJ, Dejanovic B, Zhou Y, Bohlen CJ, Lee S, Ren J, Liu A, Tang Z, Sheng H, Liu J, Sheng M, Wang X. (2023) Integrative in situ mapping of single-cell transcriptional states and tissue histopathology in a mouse model of Alzheimer's disease. Nat. Neurosci., 26: 430-446.
Aditham A, Shi H, Guo J, Zeng H, Zhou Y, Wade SD, Huang J, Liu J, Wang X. (2022) Chemically modified mocRNAs for highly efficient protein expression in mammalian cells. ACS Chem. Biol., 17: 3352-3366.
He B, Zhang C, Zhang XX, Fan Y, Zeng H, Liu JE, Meng HW, Bai DS, Peng JY, Zhang Q, Tao W, Yi CQ. (2021) Tissue-specific 5-hydroxymethylcytosine landscape of the human genome. Nat. Commun., 12: 4249.
Liu MG, Zhang J, Zhu CX, Zhang XX, Xiao WD, Yan YC, Liu LL, Zeng H, Gao YQ, Yi CQ. (2021) DNA repair glycosylase hNEIL1 triages damaged bases via competing interaction modes. Nat. Commun., 12: 4108.
唐萌、任杰、赵霄美、叶凌源、周坚、程臣、惠天啸、罗成、景智文
