焦雨铃 教授
植物器官形成研究组
北京大学生命科学学院 教授，博士生导师
电话：
E-mail：yuling.jiao@pku.edu.cn
本研究组综合单细胞转录组分析、活体成像、分子遗传学、数学建模等方法，研究植物干细胞重建和器官塑形（即形态建成），例如单细胞再生、叶片扁平化的建立。本实验室还开展合成基因组学研究，力图建立植物人工染色体技术。
1. 叶片扁平化的建立机制
叶片是最基本的植物器官，通常是主要的光合作用场所。扁平宽大的形态有利于增大光合作用的面积，是常见的叶片特征。叶片的扁平化生长是伴随叶片发育过程逐渐形成的。本实验室的研究关注扁平化建立的调控机制，特别是植物激素生长素与生物力学在扁平化建立过程的作用。
2. 干细胞重建
叶片的基部（叶腋处）能够形成新的干细胞团和分生组织，称为侧生分生组织。侧生分生组织产生侧芽，使植物能够产生分枝。开花后侧生分生组织形成花序分枝。因此，侧生干细胞的活性是决定植物形态和作物产量的重要因素。本实验室通过活体成像、转录谱分析、以及遗传分析研究侧生干细胞团重建的转录调控网络。
3. 植物人工染色体
合成生命是生命科学的新前沿。物理学家费曼说过：“What I cannot create, I do not understand”。在细菌、酵母中，科学家已经获得了完全人工合成的染色体，不仅深化了对基因组的认识，更为快速进化、重编程代谢通路提供了技术平台。在更为复杂的多细胞生物中，人工合成基因组尚未突破。本实验室与合作者力图在植物中建立基因组操作的技术体系，实现突破。
Chen LG, Lan TL, Zhang S, Zhao MK, Luo GY, Gao Y, Zhang YL, Du QW, Lu HZ, Li BM, Jiao BK, Hu ZL, Ma YX, Zhao Q, Wang Y, Qian WF, Dai JB, Jiao YL. (2024) A designer synthetic chromosome fragment functions in moss. Nat. Plants, 10: 228-239.
Du F, Dai JB, Jiao YL. (2024) Insights into a functional synthetic plant genome. New Phytol., 244: 46-50.
Li MJ, Jiao YL. (2024) Cereal genetics: novel modulators of spikelet number and flowering time. Curr. Biol., 34: R528-R530.
Chen CL, Hu YX, Ikeuchi M, Jiao YL, Prasad K, Su YH, Xiao J, Xu L, Yang WB, Zhao Z, Zhou WK, Zhou Y, Gao J, Wang JW. (2024) Plant regeneration in the new era: from molecular mechanisms to biotechnology applications. Sci. China-Life Sci., 67: 1338-1367.
Wei B, Jiao YL. (2024) Grain size control in wheat: toward a molecular understanding. Seed Biol., 3: e007.
Cao XW, Du QW, Guo YH, Wang Y, Jiao YL. (2023) Condensation of STM is critical for shoot meristem maintenance and salt tolerance in Arabidopsis. Mol. Plant., 16: 1445-1459.
Wang Y, Jiao YL. (2023) Cell signaling in the shoot apical meristem. Plant Physiol., 193: 70-82.
Gao ZX, Bian JX, Lu F, Jiao YL, He H. (2023) Triticeae crop genome biology: an endless frontier. Front. Plant Sci., 14: 1222681.
Peng ZY, Jiao YL, Wang Y. (2023) Morphogenesis of leaves: from initiation to the production of diverse shapes. Biochem. Soc. Trans., 51: 513-525.
Yang TT, Jiao YL, Wang Y. (2023) Stem cell basis of shoot branching. Plant Cell Physiol., 64: 291-296.
Xin X, Du F, Jiao YL. (2023) Plant nuclei isolation for single-nucleus RNA sequencing. Methods Mol. Biol., 2686: 307-311.
Peng ZY, Jiao YL, Wang Y. (2023) Live imaging of Arabidopsis shoot primordia via a confocal laser scanning microscope. STAR Protoc., 4: 102217.
Jiao YL, Wang Y. (2023) Towards plant synthetic genomics. BioDes. Res., 5: 0020.
Wang QQ, Marconi M, Guan CM, Wabnik K, Jiao YL. (2022) Polar auxin transport modulates early leaf flattening. Proc. Natl. Acad. Sci. U. S. A., 119: e2215569119.
Guan CM, Jiao YL. (2022) Spatiotemporal imaging clarifies leaf primordium patterning. Trends Plant Sci., 27: 1196-1198.
Yang TT, Jiao YL, Wang Y. (2022) Stem cell basis of shoot branching. Plant Cell Physiol., 23: pcac165.
Peng ZY, Alique D, Xiong YY, Hu JR, Cao XW, Lü SQ, Long M, Wang Y, Wabnik K, Jiao YL. (2022) Differential growth dynamics control aerial organ geometry. Curr. Biol., 32: 4854-4868.
Ge YH, Gao Y, Jiao YL, Wang Y. (2022) A conserved module in the formation of moss midribs and seed plant axillary meristems. Sci Adv., 8: eadd7275.
Wang YG, Du F, Wang J, Wang K, Tian CH, Qi XQ, Lu F, Liu XG, Ye XG, Jiao YL. (2022) Improving bread wheat yield through modulating an unselected AP2/ERF gene. Nat. Plants, 8: 930-939.
Hou XR, Wang DP, Cheng ZK, Wang Y, Jiao YL. (2022) A near-complete assembly of an Arabidopsis thaliana genome. Mol. Plant., 15: 1247-1250.
Guan CM, Qiao LX, Xiong YY, Zhang L, Jiao YL. (2022) Coactivation of antagonistic genes stabilizes polarity patterning during shoot organogenesis. Sci. Adv., 8: eabn0368.
Mo YJ, Jiao YL. (2022) Advances and applications of single-cell omics technologies in plant research. Plant J., 110: 1551-1563.
Zheng YF, Wang DH, Ye SD, Chen WQ, Li GL, Xu ZH, Bai SN, Zhao F. (2021) Auxin guides germ-cell specification in Arabidopsis anthers. Proc. Natl. Acad. Sci. U. S. A., 118: e2101492118.
Fu R, Li J, Yu HT, Zhang Y, Xu ZH, Martin C. (2021) The Yin and Yang of traditional Chinese and Western medicine. Med. Res. Rev., 41: 3182-3200.
Lin YN, Jiang CK, Cheng ZK, Wang DH, Shen LP, Xu C, Xu ZH, Bai SN (2021) Rice Cell Division Cycle 20s are required for faithful chromosome segregation and cytokinesis during meiosis. Plant Physiol., 188: 1111-1128.
Xu ZH. (2020) A bridge to the world. Annu. Rev. Plant Biol., 71: 1-38.
Yang ZR, Huang Y, Yang JL, Yao SZ, Zhao K, Wang DH, Qin QQ, Bian Z, Li Y, Lan Y, Zhou T, Wang H, Liu C, Wang WM, Qi YJ, Xu ZH, Li Y. (2020) Jasmonate signaling enhances RNA silencing and antiviral defense in rice. Cell Host Microbe., 28: 89-103.
关春梅、蒋陈焜、王晓静、郭亚鹤、蒲娅、康美玲、曹子宁、田文清、张晨妍、崔博飞、兰天龙、刘心怡、刘文静
