In vivo ways to unveil off-targets
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- m6A-modified cenRNA stabilizes CENPA to ensure centromere integrity in cancer cells2025.02.28
- A replisome-associated histone H3-H4 chaperone required for epigenetic inheritance2025.02.28
- Structure and topography of the synaptic V-ATPase-synaptophysin complex2025.02.28
- Parental histone transfer caught at the replication fork2025.02.28
- Structural insights into the high-affinity IgE receptor FcεRI complex2025.02.28
- Sensory circuitry controls cytosolic calcium-mediated phytochrome B phototransduction2025.02.28
- Antagonistic RALF peptides control an intergeneric hybridization barrier on Brassicaceae stigmas2025.02.28
- Immunoglobulin M perception by FcμR2025.02.28
- Palaeogenomics of upper palaeolithic to neolithic european hunter-gatherers2025.02.28
- RALF peptide signaling controls the polytubey block in Arabidopsis2023.01.18
- The evolution and diversification of oakleaf butterflies2023.01.18
- Circular RNA vaccines against SARS-CoV-2 and emerging variants2023.01.18
- Mitochondrial base editor induces substantial nuclear off-target mutations2023.01.18
- Genome-wide interrogation of gene functions through base editor screens empowered by barcoded sgRNAs2022.01.28
- RNA polymerase III is required for the repair of DNA double-strand breaks by homologous recombination2022.01.28
- Detect-seq reveals out-of-protospacer editing and target-strand editing by cytosine base editors2022.01.28
- Reply to: Fitness effects of CRISPR/Cas9-targeting of long noncoding RNA genes2021.03.10
- Structurally Resolved SARS-CoV-2 Antibody Shows High Efficacy in Severely Infected Hamsters and Provides a Potent Cocktail Pairing Strategy2021.03.10
- Structural insights into immunoglobulin M2021.03.10
- Cysteine-rich peptides promote interspecific genetic isolation in Arabidopsis2020.02.29
- Human neonatal Fc receptor is the cellular uncoating receptor for enterovirus B2020.02.29
- Programmable RNA editing by recruiting endogenous ADAR using engineered RNAs2020.02.29
- Cap-specific, terminal N-6-methylation by a mammalian m(6)Am methyltransferase2020.02.29
- In vivo ways to unveil off-targets2020.02.29
- The nucleoskeleton protein IFFO1 immobilizes broken DNA and suppresses chromosome translocation during tumorigenesis2020.02.29
- Function and evolution of upstream ORFs in eukaryotes2020.02.29
- Guide RNAs with embedded barcodes boost CRISPR-pooled screens2020.02.29
- PASTMUS: mapping functional elements at single amino acid resolution in human cells2020.02.29
- How CrRLK1L receptor complexes perceive RALF signals2020.02.29
- Structural and functional insights into the tetrameric photosystem I from heterocyst-forming cyanobacteria2020.02.29
- Interrogating the noncoding genome in a high-throughput fashion2020.02.29
- ALBA protein complex reads genic R-loops to maintain genome stability in Arabidopsis2020.02.29
- Mechanism of DNA-induced phase separation for transcriptional repressor VRN12020.02.29
- hCINAP regulates the DNA-damage response and mediates the resistance of acute myelocytic leukemia cells to therapy2020.02.29
- An expanded landscape of human long noncoding RNA2020.02.29
- Genome-wide screening for functional long noncoding RNAs in human cells by Cas9 targeting of splice sites2020.02.29
- PrePAIRing Cas9s for screening success2020.02.29
- Resequencing of 243 diploid cotton accessions based on an updated A genome identifies the genetic basis of key agronomic traits2020.02.29
- CHAF1B Overexpression: A Brake for the Differentiation of Leukemia Cells2020.02.29
- Bisulfite-ree nanoscale analysis of 5-hydroxymethylcytosine at single base resolution.2020.02.29
- Structural basis for draxin-modulated axon guidance and fasciculation by Netrin-1 through DCC2020.02.29
- Genome-wide mapping reveals that deoxyuridine is enriched in the human centromeric DNA2020.02.29
- An OB-fold complex controls the repair pathways for DNA double-strand breaks2020.02.29
- Biosynthetic energy cost for amino acids decreases in cancer evolution2020.02.29
- Structure and evolution of the Fam20 kinases2020.02.29
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- Pyrazinamide and derivatives block ethylene biosynthesis by inhibiting ACC oxidase. Nat Commun., 8: 15758.2018.03.02
- Deciphering TAL effectors for 5-methylcytosine and 5-hydroxymethylcytosine recognition. Nat Commun., 8: 901.2018.03.02
- Adenylate kinase hCINAP determines self-renewal of colorectal cancer stem cells by facilitating LDHA phosphorylation. Nat Commun., 8: 15308.2018.03.02
- Base-Resolution Mapping Reveals Distinct m1A Methylome in Nuclear- and Mitochondrial-Encoded Transcripts. Mol Cell., 68: 993-1005.2018.03.02
- Painting a specific chromosome with CRISPR/Cas9 for live-cell imaging. Cell Res., 27: 298-301.2018.03.02
- Inflammasome Activation Triggers Caspase-1-Mediated Cleavage of cGAS to Regulate Responses to DNA Virus Infection. Immunity, 46: 393-404.2018.03.02
- Single-Cell 5-Formylcytosine Landscapes of Mammalian Early Embryos and ESCs at Single-Base Resolution. Cell Stem Cell., 20: 720-731.2018.03.02
- Epitranscriptome sequencing technologies: decoding RNA modifications. Nat Methods., 14: 23-31.2018.03.02
- Arabidopsis pollen tube integrity and sperm release are regulated by RALF-mediated signaling. Science, 358: 1596-1600.2018.03.02
- RPA binds histone H3-H4 and functions in DNA replication-coupled nucleosome assembly. Science, 355: 415-420.2018.03.02
- Genome-scale deletion screening of human long non-coding RNAs using a paired-guide RNA CRISPR-Cas9 library. Nat Biotechnol., 34: 1279-1286.2018.01.19
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- microRNAs in the Same Clusters Evolve to Coordinately Regulate Functionally Related Genes. MolBiolEvol., 33: 2232-2247.2018.01.19
- Transcriptome-wide mapping reveals reversible and dynamic N-1-methyladenosine methylome. Nat Chem Biol., 12: 311-316.2018.01.19
- Base-Resolution Analysis of Cisplatin-DNA Adducts at the Genome Scale. AngewChemInt Ed Engl., 55: 14246-14249.2018.01.19
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