Chinese

Interrogating the noncoding genome in a high-throughput fashion

Prev Next

Advanced

Light-induced remodeling of phytochrome B enables signal transduction by phytochrome-interacting factor2025.02.28
m6A-modified cenRNA stabilizes CENPA to ensure centromere integrity in cancer cells2025.02.28
A replisome-associated histone H3-H4 chaperone required for epigenetic inheritance2025.02.28
Structure and topography of the synaptic V-ATPase-synaptophysin complex2025.02.28
Parental histone transfer caught at the replication fork2025.02.28
Structural insights into the high-affinity IgE receptor FcεRI complex2025.02.28
Sensory circuitry controls cytosolic calcium-mediated phytochrome B phototransduction2025.02.28
Antagonistic RALF peptides control an intergeneric hybridization barrier on Brassicaceae stigmas2025.02.28
Immunoglobulin M perception by FcμR2025.02.28
Palaeogenomics of upper palaeolithic to neolithic european hunter-gatherers2025.02.28
RALF peptide signaling controls the polytubey block in Arabidopsis2023.01.18
The evolution and diversification of oakleaf butterflies2023.01.18
Circular RNA vaccines against SARS-CoV-2 and emerging variants2023.01.18
Mitochondrial base editor induces substantial nuclear off-target mutations2023.01.18
Genome-wide interrogation of gene functions through base editor screens empowered by barcoded sgRNAs2022.01.28
RNA polymerase III is required for the repair of DNA double-strand breaks by homologous recombination2022.01.28
Detect-seq reveals out-of-protospacer editing and target-strand editing by cytosine base editors2022.01.28
Reply to: Fitness effects of CRISPR/Cas9-targeting of long noncoding RNA genes2021.03.10
Structurally Resolved SARS-CoV-2 Antibody Shows High Efficacy in Severely Infected Hamsters and Provides a Potent Cocktail Pairing Strategy2021.03.10
Structural insights into immunoglobulin M2021.03.10
Cysteine-rich peptides promote interspecific genetic isolation in Arabidopsis2020.02.29
Human neonatal Fc receptor is the cellular uncoating receptor for enterovirus B2020.02.29
Programmable RNA editing by recruiting endogenous ADAR using engineered RNAs2020.02.29
Cap-specific, terminal N-6-methylation by a mammalian m(6)Am methyltransferase2020.02.29
In vivo ways to unveil off-targets2020.02.29
The nucleoskeleton protein IFFO1 immobilizes broken DNA and suppresses chromosome translocation during tumorigenesis2020.02.29
Function and evolution of upstream ORFs in eukaryotes2020.02.29
Guide RNAs with embedded barcodes boost CRISPR-pooled screens2020.02.29
PASTMUS: mapping functional elements at single amino acid resolution in human cells2020.02.29
How CrRLK1L receptor complexes perceive RALF signals2020.02.29
Structural and functional insights into the tetrameric photosystem I from heterocyst-forming cyanobacteria2020.02.29
Interrogating the noncoding genome in a high-throughput fashion2020.02.29
ALBA protein complex reads genic R-loops to maintain genome stability in Arabidopsis2020.02.29
Mechanism of DNA-induced phase separation for transcriptional repressor VRN12020.02.29
hCINAP regulates the DNA-damage response and mediates the resistance of acute myelocytic leukemia cells to therapy2020.02.29
An expanded landscape of human long noncoding RNA2020.02.29
Genome-wide screening for functional long noncoding RNAs in human cells by Cas9 targeting of splice sites2020.02.29
PrePAIRing Cas9s for screening success2020.02.29
Resequencing of 243 diploid cotton accessions based on an updated A genome identifies the genetic basis of key agronomic traits2020.02.29
CHAF1B Overexpression: A Brake for the Differentiation of Leukemia Cells2020.02.29
Bisulfite-ree nanoscale analysis of 5-hydroxymethylcytosine at single base resolution.2020.02.29
Structural basis for draxin-modulated axon guidance and fasciculation by Netrin-1 through DCC2020.02.29
Genome-wide mapping reveals that deoxyuridine is enriched in the human centromeric DNA2020.02.29
An OB-fold complex controls the repair pathways for DNA double-strand breaks2020.02.29
Biosynthetic energy cost for amino acids decreases in cancer evolution2020.02.29
Structure and evolution of the Fam20 kinases2020.02.29
Sperm cells are passive cargo of the pollen tube in plant fertilization. Nat plants., 3: 17079.2018.03.02
ROS accumulation and antiviral defence control by microRNA528 in rice. Nat plants., 3: 16203.2018.03.02
A Radiolabeling-Free, qPCR-Based Method for Locus-Specific Pseudouridine Detection. Angew Chem Int Ed Engl., 56: 14878-14882.2018.03.02
Pyrazinamide and derivatives block ethylene biosynthesis by inhibiting ACC oxidase. Nat Commun., 8: 15758.2018.03.02
Deciphering TAL effectors for 5-methylcytosine and 5-hydroxymethylcytosine recognition. Nat Commun., 8: 901.2018.03.02
Adenylate kinase hCINAP determines self-renewal of colorectal cancer stem cells by facilitating LDHA phosphorylation. Nat Commun., 8: 15308.2018.03.02
Base-Resolution Mapping Reveals Distinct m1A Methylome in Nuclear- and Mitochondrial-Encoded Transcripts. Mol Cell., 68: 993-1005.2018.03.02
Painting a specific chromosome with CRISPR/Cas9 for live-cell imaging. Cell Res., 27: 298-301.2018.03.02
Inflammasome Activation Triggers Caspase-1-Mediated Cleavage of cGAS to Regulate Responses to DNA Virus Infection. Immunity, 46: 393-404.2018.03.02
Single-Cell 5-Formylcytosine Landscapes of Mammalian Early Embryos and ESCs at Single-Base Resolution. Cell Stem Cell., 20: 720-731.2018.03.02
Epitranscriptome sequencing technologies: decoding RNA modifications. Nat Methods., 14: 23-31.2018.03.02
Arabidopsis pollen tube integrity and sperm release are regulated by RALF-mediated signaling. Science, 358: 1596-1600.2018.03.02
RPA binds histone H3-H4 and functions in DNA replication-coupled nucleosome assembly. Science, 355: 415-420.2018.03.02
Genome-scale deletion screening of human long non-coding RNAs using a paired-guide RNA CRISPR-Cas9 library. Nat Biotechnol., 34: 1279-1286.2018.01.19
Signature motif-guided identification of receptors for peptide hormones essential for root meristem growth. Cell Res., 26: 674-685.2018.01.19
Crystal structure of PXY-TDIF complex reveals a conserved recognition mechanism among CLE peptide-receptor pairs. Cell Res., 26: 543-555.2018.01.19
microRNAs in the Same Clusters Evolve to Coordinately Regulate Functionally Related Genes. MolBiolEvol., 33: 2232-2247.2018.01.19
Transcriptome-wide mapping reveals reversible and dynamic N-1-methyladenosine methylome. Nat Chem Biol., 12: 311-316.2018.01.19
Base-Resolution Analysis of Cisplatin-DNA Adducts at the Genome Scale. AngewChemInt Ed Engl., 55: 14246-14249.2018.01.19
Bai DM, Zhang JF, Li TT, Hang RL, Liu Y, Tian YL, Huang DD, Qu LL, Cao XF, Ji JF, Zheng XF. (2016) The ATPase hCINAP regulates 18S rRNA processing and is essential for embryogenesis and tumour growth. Nat Commun., 7: 12310.2018.01.19
Li KL, Yu RB, Fan LM, Wei N, Chen HD, Deng XW. (2016) DELLA-mediated PIF degradation contributes to coordination of light and gibberellin signalling in Arabidopsis. Nat Commun., 7: 11868.2018.01.19
Li FG, Fan GY, Lu CR, Xiao GH, Zou CS, Kohel RJ, Ma ZY, Shang HH, Ma XF, Wu JY, Liang XM, Huang G, Percy RG, Liu K, Yang WH, Chen WB, Du XM, Shi CC, Yuan YL, Ye WW, Liu X, Zhang XY, Liu WQ, Wei HL, Wei SJ, Huang GD, Zhang XL, Zhu SJ, Zhang H, Sun FM, Wang XF, Liang J, Wang JH, He Q, Huang LH, Wang J, Cui JJ, Song GL, Wang KB, Xu X, Yu JZ, Zhu YX, Yu SX. (2015) Genome sequence of cultivated Upland cotton (Gossypium hirsutum TM-1) provides insights into genome evolution. Nat Biotechnol., 33: 524-5302018.01.19
Zhang XY, Zhu Y, Liu XD, Hong XY, Xu Y, Zhu P, Shen Y, Wu HH, Ji YS, Wen X, Zhang C, Zhao Q, Wang YC, Lu J, Guo HW. (2015) Suppression of endogenous gene silencing by bidirectional cytoplasmic RNA decay in Arabidopsis. Science, 348: 120-123.2018.01.19
Li W, Ma M, Feng Y, Li H, Wang Y, Ma Y, Li M, An FY, Guo HW. (2015) EIN2-Directedtranslationalregulation of ethylenesignaling in Arabidopsis. Cell, 163: 670-6832018.01.19
Xia B, Han D, Lu X, Sun Z, Zhou A, Yin Q, Zeng H, Liu M, Jiang X, Xie W, He C, Yi CQ (2015) Bisulfite-free, base-resolution analysis of 5-formylcytosine at the genome scale.Nat Methods., 12: 1047-1050.2018.01.19
Wang XJ, Cao Q, Zhang Y, Su XD. (2015) Activation and regulation of caspase-6 and its role in neurodegenerative diseases. Annu Rev PharmacolToxicol., 55: 553-572.2018.01.19
Zhao HQ, Zhang P, Gao H, He XD, Dou YM, Huang AY, Liu XM, Ye AY, Dong MQ, Wei LP. (2015) Profiling the RNA editomes of wild-type C. elegans and ADAR mutants. Genome Res., 25: 66-75.2018.01.19
Li XY, Zhu P, Ma SQ, Song JH, Bai JY, Sun FF, Yi CQ. (2015) Chemical pulldown reveals dynamic pseudouridylation of the mammalian transcriptome.Nat Chem Biol., 11: 592-597.2018.01.19
Chang LF, Liu XW, Li YB, Liu CC, Yang F, Zhao JD, Sui SF. (2015) Structural organization of an intact phycobilisome and its association with photosystem II. Cell Res., 25: 726-737.2018.01.19
Gao J, Tao JL, Liang WL, Zhao M, Du XX, Cui S, Duan HF, Kan BA, Su XD, Jiang ZF. (2015) Identification and characterization of phosphodiesterases that specifically degrade 3 ' 3 '-cyclic GMP-AMP. Cell Res., 25: 539-550.2018.01.19
Yuan PF, Zhang HM, Cai CZ, Zhu SY, Zhou YX, Yang XZ, He RN, Li C, Guo SJ, Li S, Huang TX, Perez-Cordon G, Feng HP, Wei WS. (2015) Chondroitin sulfate proteoglycan 4 functions as the cellular receptor for Clostridium difficile toxin B. Cell Res., 25: 157-168.2018.01.19
Wei BY, Zhang JZ, Pang CX, Yu H, Guo DS, Jiang H, Ding MX, Chen ZY, Tao Q, Gu HY, Qu LJ, Qin GJ. (2015) The molecular mechanism of SPOROCYTELESS/NOZZLE in controlling Arabidopsis ovule development. Cell Res., 25: 121-134.2018.01.19
He RN, Peng JY, Yuan PF, Xu F, Wei WS. (2015) Divergent roles of BECN1 in LC3 lipidation and autophagosomal function. Autophagy., 11: 740-747.2018.01.19
Yang L, Li BS, Zheng XY, Li JG, Yang M, Dong XN, He GM, An CC, Deng XW. (2015) Salicylic acid biosynthesis is enhanced and contributes to increased biotrophic pathogen resistance in Arabidopsis hybrids. Nat Commun., 6: 7309.2018.01.19
Xing MT, Yang MR, Huo W, Feng F, Wei LZ, Jiang WX, Ning SK, Yan ZX, Li W, Wang QS, Hou M, Dong CX, Guo R, Gao G, Ji JG, Zha S, Lan L, Liang HH, Xu DY. (2015) Interactome analysis identifies a new paralogue of XRCC4 in non-homologous end joining DNA repair pathway. Nat Commun., 6: 6233.2018.01.19
Zhang YZ, Jiao Y, Liu ZH, Zhu YX. (2015) ROW1 maintains quiescent centre identity by confining WOX5 expression to specific cells. Nat Commun., 6: 6003.2018.01.19
Shi H, Wang X, Mo XR, Tang C, Zhong SW, Deng XW. (2015) Arabidopsis DET1 degrades HFR1 but stabilizes PIF1 to precisely regulate seed germination. ProcNatlAcadSci U S A., 112: 3817-3822.2018.01.19
Guo D, Zhang J, Wang X, Han X, Wei B, Wang J, Li B, Yu H, Huang Q, Gu H, Qu L-J, Qin GJ(2015) The WRKY transcription factor WRKY71/EXB1 controls shoot branching by transcriptionally regulating RAX genes in Arabidopsis. Plant Cell, 27: 3112-3127.2018.01.19
Lin Q, Ogashi Y, Kato M, Tsuge T, Gu H, Qu LJ, Aoyama T. (2015) GLABRA2 targets basic Helix-loop-helix transcription factor genes to robustly suppress root hair development. Plant Cell, 27: 2894-2906.2018.01.19
Wu JG, Yang ZR, Wang Y, Zheng LJ, Ye RQ, Ji YH, Zhao SS, Ji SY, Liu RF, Xu L, Zheng H, Zhou YJ, Zhang X, Cao XF, Xie LH, Wu ZJ, Qi YJ, Li Y. (2015) Viral-Inducible argonaute18 confers broad-spectrum virus resistance in rice by sequestering a host microRNA. Elife., 4:e05733. DOI: 10.7554/eLife.05733.2018.01.19
Jin JP, He K, Tang X, Li Z, Lv L, Zhao Y, Luo JC, Gao G. (2015) An Arabidopsis transcriptional regulatory map reveals distinct functional and evolutionary features of novel transcription factors. MolBiolEvol., 32: 1767-1773.2018.01.19
Huang, X; Ouyang, X; Deng, XW.(2014) Beyond repression of photomorphogenesis: role switching of COP/DET/FUS in light signaling. Curr Opin Plant Biol 21: 96-103.2018.01.19
Dong, J; Tang, D; Gao, Z; Yu, R; Li, K; He, H; Terzaghi, W; Deng, X.W; and Chen, HD. (2014) Arabidopsis DE-ETIOLATED1 represses photomorphogenesis by positively regulating phytochrome-interacting factors in the dark. Plant Cell 26: 3630-3645.2018.01.19
Zhang, X; Zhu, ZQ; An, FY; Hao, DD; Li, PP; Song, JH; Yi, CQ;Guo, HW. (2014) Jasmonate-Activated MYC2 Represses ETHYLENE INSENSITIVE3 Activity to Antagonize Ethylene-Promoted Apical Hook Formation in Arabidopsis. Plant Cell 26: 1105-1117.2018.01.19
Xu, DQ; Lin, F; Jiang, Y; Huang, X; Li, JG; Ling, JJ; Hettiarachchi, C; Tellgren-Roth, C; Holm, M; Deng, XW. (2014) The RING-Finger E3 Ubiquitin Ligase COP1 SUPPRESSOR1 Negatively Regulates COP1 Abundance in Maintaining COP1 Homeostasis in Dark-Grown Arabidopsis Seedlings. Plant Cell 26: 1981-1991.2018.01.19
Chen, F; Li, BS; Li, G; Charron, JB; Dai, MQ; Shi, XR; Deng, XW. (2014) Arabidopsis Phytochrome A Directly Targets Numerous Promoters for Individualized Modulation of Genes in a Wide Range of Pathways. Plant Cell 26: 1949-19662018.01.19
Zhong, SW; Shi, H; Xue, C; Wei, N; Guo, HW; Deng, XW. (2014) Ethylene-orchestrated circuitry coordinates a seedling's response to soil cover and etiolated growth. Proc. Natl. Acad. Sci. U. S. A. 111: 3913-39202018.01.19
Yang, JG; Xie, XQ; Wang, X; Dixon, R; Wang, YP. (2014) Reconstruction and minimal gene requirements for the alternative iron-only nitrogenase in Escherichia coli. Proc. Natl. Acad. Sci. U. S. A. 111: E3718-E37252018.01.19
Wang, YQ; Fan, XD; Lin, F; He, GM; Terzaghi, W; Zhu, DM; Deng, XW. (2014) Arabidopsis noncoding RNA mediates control of photomorphogenesis by red light. Proc. Natl. Acad. Sci. U. S. A. 111: 10359-10364.2018.01.19
Wang, LH; Li, JG; Zhou, Q; Yang, GM; Ding, XL; Li, XD; Cai, CX; Zhang, Z; Wei, HY; Lu, TH; Deng, XW; Huang, XH. (2014) Rare earth elements activate endocytosis in plant cells. Proc. Natl. Acad. Sci. U. S. A. 111: 12936-12941.2018.01.19
Ouyang, XH; Huang, X; Jin, X; Chen, Z; Yang, PY; Ge, H; Li, SG; Deng, XW. (2014) Coordinated photomorphogenic UV-B signaling network captured by mathematical modeling. Proc. Natl. Acad. Sci. U. S. A. 111: 11539-115442018.01.19
Chen, F; Li, BS; Demone, J; Charron, JB; Shi, XR; Deng, XW. (2014) Photoreceptor partner FHY1 has an independent role in gene modulation and plant development under far-red light. Proc. Natl. Acad. Sci. U. S. A. 111: 11888-11893.2018.01.19
Cao, MJ; Du, P; Wang, XB; Yu, YQ; Qiu, YH; Li, WX; Gal-On, A; Zhou, CY; Li, Y; Ding, SW. (2014) Virus infection triggers widespread silencing of host genes by a distinct class of endogenous siRNAs in Arabidopsis. Proc. Natl. Acad. Sci. U. S. A. 111: 14613-14618.2018.01.19
我室孔道春实验室阐明真核细胞岗崎片段加工成熟的分子机制2017.05.04