Plant microRNA maturation and function
Prof. Xuemei Chen published a review in Nature Reviews Molecular Cell Biology.
Since their discovery in 2002, much has been learnt about plant microRNAs (miRNAs), including the genes that encode them and the target genes that they regulate; the microprocessor complex that produces the miRNAs and the effector ARGONAUTE (AGO) proteins with which miRNAs associate; the mechanisms of target-RNA recognition by miRNAs and miRNA modes of action; miRNA subcellular localization; and miRNA mobility between cells and within plants. In this Review, we discuss new mechanistic insights into miRNA maturation and AGO loading, the subcellular locations of miRNA processing and activity and partitioning of miRNAs between the nucleus and cytoplasm, which in turn affects their intercellular mobility. We also discuss intriguing connections between miRNAs and the translation process and present hypotheses to be tested by future studies.
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- Plant microRNA maturation and function2025.07.23
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- Genome synthesis in plants2025.07.09
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- Learning Phenotype Associated Signature in Spatial Transcriptomics with PASSAGE2025.02.12
- Dynamic changes in 3D chromatin structure during the two rounds of mitosis in plant male gametogenesis2025.02.12
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- MicroRNA analysis reveals two modules that antagonistically regulate xylem tracheary element development in Arabidopsis2025.01.19
- Promoter capture Hi-C identifies promoter-related loops and fountain structures in Arabidopsis2025.01.02
- Quantifying the regulatory potential of genetic variants via a hybrid sequence-oriented model with SVEN2025.01.02
- Mapping functional elements of the DNA damage response through base editor screens2024.12.16
- The Arabidopsis RING-type E3 ligase TEAR4 Controls Seed Germination by Targeting RGA for Degradation2024.12.05
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- Programmable DNA pyrimidine base editing via engineered uracil-DNA glycosylase2024.08.03
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- Lysine L-lactylation is the dominant lactylation isomer induced by glycolysis2024.07.22
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- Arabidopsis transcription factor TCP4 controls the identity of the apical gynoecium2024.04.08
- Adaptive Functions of Structural Variants in Human Brain Developmen2024.04.07
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- Modeling viral evolution: A novel SIRSVIDE framework with application to SARS-CoV-2 dynamics2024.03.28
- Toll/interleukin-1 receptor (TIR) domain-containing proteins have NAD-RNA decapping activity2024.03.18
- Parental histone transfer caught at the replication fork2024.03.07
- Near-cognate tRNAs increase the efficiency and precision of pseudouridine-mediated readthrough of premature termination codons2024.03.06
- Unsynchronized butyrophilin molecules dictate cancer cell evasion of Vγ9Vδ2 T-cell killing2024.02.21
- Rice transcriptional repressor OsTIE1 controls anther dehiscence and male sterility by regulating JA biosynthesis2024.02.21
- Molecular Insights into the Adaptive Evolution of SARS-CoV-2 Spike Protein2024.02.20
- An oscillatory transcription factor complex in Dictyostelium enables adaptive changes in macropinocytosis during the growth-to-development transition2024.02.19
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- Age-related noncanonical TRMT6–TRMT61A signaling impairs hematopoietic stem cells2024.01.18
- Molecular evolution of protein ssequences and codon usage in monkeypox viruses2023.12.15
- Convergent and divergent evolution of microRNA-mediated regulation in metazoans2023.11.24
- Unbiased interrogation of functional lysine residues in human proteome2023.11.23
- The diversification of butterfly wing patterns: Progress and prospects2023.11.22
- Vimentin regulates nuclear segmentation in neutrophils2023.11.21
- Diurnal switches in diazotrophic lifestyle increase nitrogen contribution to cereals2023.11.20
- Spatial-linked alignment tool (SLAT) for aligning heterogenous slices2023.11.13
- Utilizing AAV-mediated LEAPER 2.0 for programmable RNA editing in non-human primates and nonsense mutation correction in humanized Hurler syndrome mice2023.10.25
- 6mA-Sniper: Quantifying 6mA Sites in Eukaryotes at Single-Nucleotide Resolution2023.10.23
- Antagonistic RALF peptides control an intergeneric hybridization barrier on Brassicaceae stigmas2023.10.08
- Organelle-dependent polyprotein designs enable stoichiometric expression of nitrogen fixation components targeted to mitochondria2023.09.18
- Arabidopsis TCP4 transcription factor inhibits high temperature induced homeotic conversion of ovules2023.09.15
- Condensation of STM is critical for shoot meristem maintenance and salt tolerance inArabidopsis2023.09.12
- Ancient DNA reveals genetic admixture in China during tiger evolution2023.09.01
- Phenolic acid-induced phase separation and translation inhibition mediate plant interspecific competition2023.08.29
- Cryo-EM and femtosecond spectroscopic studies provide mechanistic insight into the energy transfer in CpcL-phycobilisomes2023.07.10
- ATM–ESCO2–SMC3 axis promotes 53BP1 recruitment in response to DNA damage and safeguards genome integrity by stabilizing cohesin complex2023.07.10
- Regulation and functions of non-m6A mRNA modifications2023.07.04
- SENP1 decreases RNF168 phase separation to promote DNA damage repair and drug resistance in colon cancer2023.07.03
- A practical multicellular sample preparation pipeline broadens the application of in situ cryo-electron tomography2023.06.16
- Potential and progress of studying mountain biodiversity by means of butterfly genetics and genomics2023.06.12
- Optimization and deoptimization of codons in SARS-CoV-2 and related implications for vaccine development2023.06.05
- Inferring historical introgression with deep learning2023.06.01
- Genome-wide identification of gene loss events suggests loss relics as a potential source of functional lncRNAs in humans2023.05.29
- Strand-selective base editing of human mitochondrial DNA using mitoBEs2023.05.23
- DDT-RELATED PROTEIN4–IMITATION SWITCH alters nucleosome distribution to relieve transcriptional silencing in Arabidopsis2023.05.23
- Imperfect ant mimicry contributes to local adaptation in a jumping spider2023.05.18
- Plasmodium falciparum has evolved multiple mechanisms to hijack human immunoglobulin M2023.05.09
- Aptamer-based nanointerferometer enables amplification-free ultrasensitive detection and differentiation of SARS-CoV-2 variants2023.04.21
- Binding by the Polycomb complex component BMI1 and H2A monoubiquitination shape local and long-range interactions in the Arabidopsis genome2023.04.19
- Adaptive evolution of the Spike protein in coronaviruses2023.04.17
- Microspore expressed SCULP1 is required forp-coumaroylation of sporopollenin, exine integrity, and pollen development in wheat2023.03.31
- Immunoglobulin M Perception by FcμR2023.03.23
- Sensory circuitry controls cytosolic calcium-mediated phytochrome B phototransduction2023.03.17