Advances in Spatial Omics Technologies
Dr. Hu Zeng published a review in Small Methods.
Rapidly developing spatial omics technologies provide us with new approaches to deeply understanding the diversity and functions of cell types within organisms. Unlike traditional approaches, spatial omics technologies enable researchers to dissect the complex relationships between tissue structure and function at the cellular or even subcellular level. The application of spatial omics technologies provides new perspectives on key biological processes such as nervous system development, organ development, and tumor microenvironment. This review focuses on the advancements and strategies of spatial omics technologies, summarizes their applications in biomedical research, and highlights the power of spatial omics technologies in advancing the understanding of life sciences related to development and disease.
- Root microbiota regulates tiller number in rice2025.04.24
- A two-step self-pollination mechanism maximizes fertility in Brassicaceae2025.04.15
- Advances in Spatial Omics Technologies2025.04.06
- The emerging role of protein l-lactylation in metabolic regulation and cell signalling2025.04.04
- DNA–protein binding is dominated by short anchoring elements2025.04.01
- Massively parallel interrogation of human functional variants modulating cancer immunosurveillance2025.03.21
- Crop root bacterial and viral genomes reveal unexplored species and microbiome patterns2025.03.13
- CTDP1 and RPB7 stabilize Pol II and permit reinitiation2025.03.05
- Genome-coverage single-cell histone modifications for embryo lineage tracing2025.03.04
- Molecular glue for phycobilisome attachment to photosystem II in Synechococcus sp. PCC 70022025.02.17
- Learning Phenotype Associated Signature in Spatial Transcriptomics with PASSAGE2025.02.12
- Dynamic changes in 3D chromatin structure during the two rounds of mitosis in plant male gametogenesis2025.02.12
- Precise modelling of mitochondrial diseases using optimized mitoBEs2025.01.23
- MicroRNA analysis reveals two modules that antagonistically regulate xylem tracheary element development in Arabidopsis2025.01.19
- Promoter capture Hi-C identifies promoter-related loops and fountain structures in Arabidopsis2025.01.02
- Quantifying the regulatory potential of genetic variants via a hybrid sequence-oriented model with SVEN2025.01.02
- Mapping functional elements of the DNA damage response through base editor screens2024.12.16
- The Arabidopsis RING-type E3 ligase TEAR4 Controls Seed Germination by Targeting RGA for Degradation2024.12.05
- Development of an inducible DNA barcoding system to understand lineage changes in Arabidopsis regeneration2024.11.26
- EMF1 functions as a 3D chromatin modulator in Arabidopsis2024.11.22
- PWOs repress gene transcription by regulating chromatin structures in Arabidopsis2024.11.22
- Multifaceted roles of TCP transcription factors in fate determination2024.10.28
- CD98hc promotes drug resistance in extranodal natural killer/T cell lymphoma through tumor cell–derived small extracellular vesicles2024.09.30
- CD5L associates with IgM via the J chain2024.09.30
- Genome-wide impact of codon usage bias on translation optimization in Drosophila melanogaster2024.09.30
- Functional profiling of serine, threonine and tyrosine sites2024.09.24
- Light-induced remodeling of phytochrome B enables signal transduction by phytochrome-interacting factor2024.09.24
- m6A-modified cenRNA stabilizes CENPA to ensure centromere integrity in cancer cells2024.09.23
- Proteasome resides in and dismantles plant heat stress granules constitutively2024.08.22
- Structural insights into the high-affinity IgE receptor FcεRI complex2024.08.22
- DNA polymerase δ subunit Pol32 binds histone H3-H4 and couples nucleosome assembly with Okazaki fragment processing2024.08.13
- Programmable DNA pyrimidine base editing via engineered uracil-DNA glycosylase2024.08.03
- A replisome-associated histone H3-H4 chaperone required for epigenetic inheritance2024.08.02
- Lysine L-lactylation is the dominant lactylation isomer induced by glycolysis2024.07.22
- Structure and topography of the synaptic V-ATPase–synaptophysin complex2024.06.06
- The microRNA408–plantacyanin module balances plant growth and drought resistance by regulating reactive oxygen species homeostasis in guard cells2024.05.16
- From sub-Saharan Africa to China: Evolutionary history and adaptation of Drosophila melanogaster revealed by population genomics2024.04.19
- Origin of functional de novo genes in humans from “hopeful monsters”2024.04.16
- Arabidopsis transcription factor TCP4 controls the identity of the apical gynoecium2024.04.08
- Adaptive Functions of Structural Variants in Human Brain Developmen2024.04.07
- Architecture and activation of human muscle phosphorylase kinase2024.04.01
- Modeling viral evolution: A novel SIRSVIDE framework with application to SARS-CoV-2 dynamics2024.03.28
- Toll/interleukin-1 receptor (TIR) domain-containing proteins have NAD-RNA decapping activity2024.03.18
- Parental histone transfer caught at the replication fork2024.03.07
- Near-cognate tRNAs increase the efficiency and precision of pseudouridine-mediated readthrough of premature termination codons2024.03.06
- Unsynchronized butyrophilin molecules dictate cancer cell evasion of Vγ9Vδ2 T-cell killing2024.02.21
- Rice transcriptional repressor OsTIE1 controls anther dehiscence and male sterility by regulating JA biosynthesis2024.02.21
- Molecular Insights into the Adaptive Evolution of SARS-CoV-2 Spike Protein2024.02.20
- An oscillatory transcription factor complex in Dictyostelium enables adaptive changes in macropinocytosis during the growth-to-development transition2024.02.19
- A designer synthetic chromosome fragment functions in moss2024.01.27
- Age-related noncanonical TRMT6–TRMT61A signaling impairs hematopoietic stem cells2024.01.18
- Molecular evolution of protein ssequences and codon usage in monkeypox viruses2023.12.15
- Convergent and divergent evolution of microRNA-mediated regulation in metazoans2023.11.24
- Unbiased interrogation of functional lysine residues in human proteome2023.11.23
- The diversification of butterfly wing patterns: Progress and prospects2023.11.22
- Vimentin regulates nuclear segmentation in neutrophils2023.11.21
- Diurnal switches in diazotrophic lifestyle increase nitrogen contribution to cereals2023.11.20
- Spatial-linked alignment tool (SLAT) for aligning heterogenous slices2023.11.13
- Utilizing AAV-mediated LEAPER 2.0 for programmable RNA editing in non-human primates and nonsense mutation correction in humanized Hurler syndrome mice2023.10.25
- 6mA-Sniper: Quantifying 6mA Sites in Eukaryotes at Single-Nucleotide Resolution2023.10.23
- Antagonistic RALF peptides control an intergeneric hybridization barrier on Brassicaceae stigmas2023.10.08
- Organelle-dependent polyprotein designs enable stoichiometric expression of nitrogen fixation components targeted to mitochondria2023.09.18
- Arabidopsis TCP4 transcription factor inhibits high temperature induced homeotic conversion of ovules2023.09.15
- Condensation of STM is critical for shoot meristem maintenance and salt tolerance inArabidopsis2023.09.12
- Ancient DNA reveals genetic admixture in China during tiger evolution2023.09.01
- Phenolic acid-induced phase separation and translation inhibition mediate plant interspecific competition2023.08.29
- Cryo-EM and femtosecond spectroscopic studies provide mechanistic insight into the energy transfer in CpcL-phycobilisomes2023.07.10
- ATM–ESCO2–SMC3 axis promotes 53BP1 recruitment in response to DNA damage and safeguards genome integrity by stabilizing cohesin complex2023.07.10
- Regulation and functions of non-m6A mRNA modifications2023.07.04
- SENP1 decreases RNF168 phase separation to promote DNA damage repair and drug resistance in colon cancer2023.07.03
- A practical multicellular sample preparation pipeline broadens the application of in situ cryo-electron tomography2023.06.16
- Potential and progress of studying mountain biodiversity by means of butterfly genetics and genomics2023.06.12
- Optimization and deoptimization of codons in SARS-CoV-2 and related implications for vaccine development2023.06.05
- Inferring historical introgression with deep learning2023.06.01
- Genome-wide identification of gene loss events suggests loss relics as a potential source of functional lncRNAs in humans2023.05.29
- Strand-selective base editing of human mitochondrial DNA using mitoBEs2023.05.23
- DDT-RELATED PROTEIN4–IMITATION SWITCH alters nucleosome distribution to relieve transcriptional silencing in Arabidopsis2023.05.23
- Imperfect ant mimicry contributes to local adaptation in a jumping spider2023.05.18
- Plasmodium falciparum has evolved multiple mechanisms to hijack human immunoglobulin M2023.05.09
- Aptamer-based nanointerferometer enables amplification-free ultrasensitive detection and differentiation of SARS-CoV-2 variants2023.04.21
- Binding by the Polycomb complex component BMI1 and H2A monoubiquitination shape local and long-range interactions in the Arabidopsis genome2023.04.19
- Adaptive evolution of the Spike protein in coronaviruses2023.04.17
- Microspore expressed SCULP1 is required forp-coumaroylation of sporopollenin, exine integrity, and pollen development in wheat2023.03.31
- Immunoglobulin M Perception by FcμR2023.03.23
- Sensory circuitry controls cytosolic calcium-mediated phytochrome B phototransduction2023.03.17
- Palaeogenomics of Upper Palaeolithic to Neolithic European hunter-gatherers2023.03.02
- Functional importance and divergence of plant apurinic/apyrimidinic endonucleases in somatic and meiotic DNA repair2023.03.01
- Cryo-Electron Tomography of Toxoplasma gondii Indicates That the Conoid Fiber May Be Derived from Microtubules2023.02.27
- hCINAP controls lineage differentiation of embryonic stem cells by regulating NEDD4 liquid-liquid phase separation-mediated YAP1 activation2023.01.31
- CRISPR-free, programmable RNA pseudouridylation to suppress premature termination codons2022.12.16
- Polar auxin transport modulates early leaf flattening2022.12.08
- From molecular basics to agronomic benefits: Insights into noncoding RNA-mediated gene regulation in plants2022.12.05
- The PtoTCP20-miR396d-PtoGRF15 module regulates the secondary vascular development in Populus2022.11.30
- The noncoding RNA HIDDEN TREASURE 1 promotes phytochrome B-dependent seed germination by repressing abscisic acid biosynthesis2022.11.27
- OsMADS58 Stabilizes Gene Regulatory Circuits during Rice Stamen Development2022.11.01
- Absolute quantification of single-base m6A methylation in the mammalian transcriptome using GLORI2022.10.28
- Differential growth dynamics control aerial organ geometry2022.10.24
- Widespread gene expression divergence in butterfly sensory tissues plays a fundamental role during reproductive isolation and speciation2022.10.18
- Miniature inverted-repeat transposable elements drive rapid microRNA diversification in angiosperms2022.10.17
- Activation Tagging Identifies WRKY14 as a Repressor of Plant Thermomorphogenesis in Arabidopsis2022.09.27