Hu Zeng, Ph.D
Spatiotemporal biology research group
Assistant Professor, College of Future Technology, Peking University
tel：
E-mail：huzeng@pku.edu.cn
1. Developing spatiotemporal multi-omics technologies
2. Deciphering gene regulatory network
3. Exploring the pathogenic mechanisms of diseases
The research work centers around the "central dogma" and integrates perse disciplines such as biology, chemistry, and physics to establish sequencing technologies with temporal, spatial, and single-cell resolution. These technologies were used to investigate gene expression regulation and the pathogenic mechanisms of diseases. Specifically, this includes: 1) the development of spatial translatomics technology to reveal subcellular localization, cell cycle, cell type, and brain region-specific translation regulation; 2) the development of spatial transcriptome and protein co-mapping technology to map the pathological profiles of brain tissue in Alzheimer's disease mouse models; 3) the development of spatiotemporal transcriptomics technology to unveil RNA dynamics at the subcellular scale.
Zeng H, Huang J, Ren J, Wang CK, Tang Z, Zhou H, Zhou Y, Shi H, Aditham A, Sui X, Chen H, Lo JA, Wang X. (2023) Spatially Resolved single-cell translatomics at molecular resolution. Science, 380: eadd3067.
Ren J, Zhou H, Zeng H, Wang CK, Huang J, Qiu X, Sui X, Li Q, Wu X, Lin Z, Lo JA, Maher K, He Y, Tang X, Lam J, Chen H, Li B, Fisher DE, Liu J, Wang X. (2023) Spatiotemporally resolved transcriptomics reveals the subcellular RNA kinetic landscape. Nat. Methods, 20: 695-705.
Zeng H, Huang J, Zhou H, Meilandt WJ, Dejanovic B, Zhou Y, Bohlen CJ, Lee S, Ren J, Liu A, Tang Z, Sheng H, Liu J, Sheng M, Wang X. (2023) Integrative in situ mapping of single-cell transcriptional states and tissue histopathology in a mouse model of Alzheimer's disease. Nat. Neurosci., 26: 430-446.
Aditham A, Shi H, Guo J, Zeng H, Zhou Y, Wade SD, Huang J, Liu J, Wang X. (2022) Chemically modified mocRNAs for highly efficient protein expression in mammalian cells. ACS Chem. Biol., 17: 3352-3366.
He B, Zhang C, Zhang XX, Fan Y, Zeng H, Liu JE, Meng HW, Bai DS, Peng JY, Zhang Q, Tao W, Yi CQ. (2021) Tissue-specific 5-hydroxymethylcytosine landscape of the human genome. Nat. Commun., 12: 4249.
Liu MG, Zhang J, Zhu CX, Zhang XX, Xiao WD, Yan YC, Liu LL, Zeng H, Gao YQ, Yi CQ. (2021) DNA repair glycosylase hNEIL1 triages damaged bases via competing interaction modes. Nat. Commun., 12: 4108.
Meng Tang, J Ren, Xiaomei Zhao, Lingyuan Ye, Jian Zhou, Chen Cheng, Tianxiao Hui, Cheng Luo, Zhiwen Jing
