An important bottleneck in current biological and medical research is the lack of modular and programmable genetic technology to accurately monitor and manipulate specific cell types and cell states. How to construct therapeutic drugs that can accurately affect specific cell types or specific cell states; at the same time, how to modify and manipulate target cell groups in an accurate way is a great challenge for precision medicine. My previous work was devoted to the development and application of genetic technology in the nervous system, and I invented CellREADR: a new cell monitoring and manipulation technology based on RNA sensors. On the basis of previous research, my laboratory will develop the monitoring and manipulation technology of the next generation of cell types and cell states; explore the application of new RNA technologies to translational medicine and promote the development of "programmable medicine". We plan to explore the marking and manipulation methods of new small glial cells, explore their role in Alzheimer's disease and aging, and develop potential new RNA-based tools and methods; we also pay attention to the engineering marking and "rewriting" new functions of various types of immune cells. The previous work was published in Nature, Neuron and other journals, and applied for many patents.

Yanjie Sun, Ningxin Jin, Shuhan Huang, Xianglei Cao, Yali Zhang, Hongda Yin, Haozhe Han, Feiyu Li, Wenli Xu, Yujie Chen