Chuan-Yun Li, Ph.D.
Laboratory of Bioinformatics and Genomic Medicine
Associate Professor, College of Future Technology, Peking University
tel：
E-mail：chuanyunli@pku.edu.cn
Taking the advantages of rhesus macaque as a model animal closely-related to human, we addressed the fundamental question of the genetic basis underlying human-specific traits.
Dr. Li’s lab addressed the fundamental question of the genetic basis underlying human-specific traits, with the interdisciplinary research of life science and information science. He introduced the cutting-edge information technologies into the field of non-human primate research to solve the major technical bottlenecks in the field, and developed the RhesusBase, a well-recognized system to support high-resolution mechanism and functional studies in Rhesus macaque. In the framework of RhesusBase, he identified an accurate list of human-specific genes and regulatory events, proposed new models on the origination and evolution of these new genetic elements, and experimentally verified the functions of two newly-originated de novo genes in human brain development. Overall, he published 21 articles as the corresponding authors on journals such as Nature Ecology & Evolution, PNAS and Science Advances, which were featured by journals such as Science. he was supported by the National Science Fund for Excellent Young Scholars of China, and the top-notch young talents supporting program, and received multiple awards such as the "Bei Shizhang Young Biophysicist Award". His PhD students also received awards such as the well-recognized "Ray Wu Prize".
Ding WQ, Li XS , Zhang J, Ji MJ , Zhang ML, Zhong XM, Cao Y, Liu XG, Li CQ, Xiao CF, Wang JX , Li T, Yu Q, Mo F, Zhang BY, Qi JH, Yang JC, Qi JT, Tian L, Xu XW, Peng Q, Zhou WZ, Liu ZJ, Fu AS, Zhang XQ, Zhang JJ, Sun YJ, Hu BY, An NA, Zhang L, Li CY. (2024) Adaptive functions of structural variants in human brain development.Sci. Adv., 10: eadl4600.
Ji MJ, Yu Q, Yang XZ, Yu XH, Wang JX, Xiao CF, An NA, Han CH, Li CY, Ding WQ. (2024) Long-range alternative splicing contributes to neoantigen specificity in glioblastoma. Brief. Bioinform., 25: bbae503.
Xiao CF, Mo F, Lu YF, Xiao Q, Yao C, Li T, Qi JH, Liu XG, Chen JY, Zhang L, Guo TN, Hu BY, An NA, Li CY. (2024) Reply to: Identification of old coding regions disproves the hominoid de novo status of genes. Nat. Ecol. Evol., 8: 1831-1834.
Liu XG, Xiao CF, Xu XW, Zhang J, Mo F, Chen JY, Delihas N, Zhang L, An NA, Li CY. (2024) Origin of functional de novo genes in humans from “hopeful monsters. WIREs RNA, 15: e1845.
Ding WQ, Li XS, Zhang J, Ji MJ, Zhang ML, Zhong XM, Cao Y, Li CQ, Liu XG, Xiao CF, Li T, Yu Q, Mo F,Zhang BY, Qi, JH Yang JC, Wang JX, Qi JT, Tian L, Xu XW, Peng Q, Zhou WZ,Liu ZJ, Fu AS, An NA, Zhang XQ, Zhang JJ, Hu BY, Sun YJ, Zhang L, Li CY. (2024) Adaptive structural variants encode human uniqueness in brain developments. Science Advances, in revision
Zhang J, Peng Q, Ma CC, Xiao CF, Li T, Liu XG, Zhou LK, Zhou WZ, Ding WQ, An NA, LiuY,Li CY. (2023) 6mA-Sniper: quantifying 6mA sites in eukaryotes at single-nucleotide resolution. Science Advances, 9: eadh7912.
Li XS, Xiao CF, Qi JT, Xue WZ, Xu XW, Mu ZL, Zhang J, Li CY, Ding WQ. (2023) STellaris: a web server for accurate spatial mapping of single cells based on spatial transcriptomics data. Nucleic Acids Research, 51: W560-W568.
Ma CC, Xue TL, Peng Q, Zhang J, Guan JL, Ding WQ, Li Y, Xia PX, Zhou LK, Zhao TY, Wang S, Quan L, Li CY, Liu Y. (2023) N6-Deoxyadenine methyltransferase modulates C. elegans immunity via dichotomous mechanisms. Cell Research, 33: 628-639.
Qi JH, Mo F, An NA, Mi TW, Wang JX, Qi JT, Li XS, Zhang BY, Xia LK, Lu YF, Sun GY, Wang XY, Li CY, Hu BY. (2023) A human-specific de novo protein promotes cortical expansion and folding. Advanced Science, 10: e2204140.
An NA, Zhang J, Mo F, Luan XK, Shen QS, Li XS, Li CQ, Tian L, Zhang BY, Qi JT, Ji MJ, Qi JH, Zhou WZ, Ding WQ, Zhang L, Chen JY, Shu SK, Hu BY, Li CY. (2023) Human-specific genes with an lncRNA origin encode unique human brain developmental functionality. Nature Ecology & Evolution, 7: 264-278.
Li YM, Shen QS, Peng Q, Ding WQ, Zhang J, Zhong XM, An NA, Ji MJ, Zhou WZ,Li CY. (2021) Polyadenylation-related isoform switching in human evolution revealed by full-length transcript structure. Briefings in Bioinformatics, 22: bbab157.
Shao LW, Peng Q, Dong MY, Gao KY, Li YM, Li Y, Li CY, Liu Y. (2020) Histone deacetylase HDA-1 modulates mitochondrial stress response and longevity. Nature Communications, 11: 4639.
Ni A An, Xiaoge Liu, Mingjun Ji, Chunfu Xiao, Ting Li, Jiaxin Wang, Juntian Qi, Chunqiong Li, Shuhan Yang, Xinwei Xu, Chao Yao, Yinuo Xie
