Di Zhang, Ph.D.
Glucose and lipid metabolism and chromatin biology
Assistant Professor, College of Life Sciences, Peking University
tel：
E-mail：zhangdi@pku.edu.cn
1. Identification of new modifications that are induced by metabolites.
2. New functions of old enzyme in cellular metabolic pathways.
3. Molecular mechanisms and functional studies on the regulation of chromatin activities by metabolites.
1. Identification of a new type of histone modification, which is induced by lactic acid----lysine lactylation.
2. Identification of a new type of histone modification, which is induced by ketone body----lysine b-hydroxybutyrylation.
These novel histone modifications of metabolite origin function to integrate cellular metabolic states and regulate gene transcription to help cells adapt to stimuli and changes in internal and external environmental signals.
Ren HW, Tang YW, Zhang D. (2025) The emerging role of protein l-lactylation in metabolic regulation and cell signaling. Nat. Metab., 7: 647-664.
Zhang D, Gao JJ, Zhu ZJ, Mao QY, Xu ZQ, Singh PK, Rimayi CC, Moreno-Yruela C, Xu SL, Li GY, Sin YC, Chen Y, Olsen CA, Snyder NW, Dai LZ, Li LJ, Zhao YM. (2025) Lysine l-lactylation is the dominant lactylation isomer induced by glycolysis. Nat. Chem. Biol., 21: 91-99.
Gao JJ, Liu RL, Huang K, Li ZY, Sheng XL, Chakraborty K, Han C, Zhang D, Becker L, Zhao YM. (2025). Dynamic investigation of hypoxia-induced L-lactylation. Proc Natl Acad Sci U S A., 122: e2404899122.
Ren HW, Zhang D. (2024) Lactylation constrains OXPHOS under hypoxia. Cell Res., 34: 91-92.
Gao JJ, Sheng XL, Du JF, Zhang D, Han C, Chen Y, Wang C, Zhao YM. (2023) Identification of 113 new histone marks by CHiMA, a tailored database search strategy. Sci. Adv.,9: eadf1416.
Moreno-Yruela C, Zhang D, Wei W, Bæk M, Liu W, Gao J, Danková D, Nielsen AL, Bolding JE, Yang L, Jameson ST, Wong J, Olsen CA, Zhao Y. (2022) Class I histone deacetylases (HDAC1-3) are histone lysine delactylases. Sci Adv., 8: eabi6696.
Huang H, Zhang D, Weng Y, Delaney K, Tang Z, Yan C, Qi S, Peng C, Cole PA, Roeder RG, Zhao Y (2021). The regulatory enzymes and protein substrates for the lysine β-hydroxybutyrylation pathway. Sci Adv. 7: eabe2771.
Shiyou Liu, Mengyuan Tian, Congcong Fu, Jiazhen Lu, Qianying Mao, Lijun Wen, La Jin, Haowen Ren, Wenyu Wang, Xiaoyu Duan, Jiahui Liang
