Jun Liu, Ph.D.
RNA modification and ncRNA function
Assistant Professor, College of Life Sciences, Peking University
tel：
E-mail：junliu1223@pku.edu.cn
1. The new regulatory mechanism of RNA modifications on chromatin structure and gene transcription, and their related biological functions in stem cell fate determination, cell reprogramming, senescence and cancer.
2. The regulatory mechanism of functional non-coding RNA and related biological functions.
3. The regulatory mechanism of RNA modification/ncRNA on phase separation and the corresponding biological functions.
1. Demonstrated a new layer of chromatin state and transcription regulation by m6A-modified chromosome-associated RNA (carRNA).
2. Discovered the new regulatory mechanisms of how aberrant m6A methylation affecting cancer progression.
3. Discovered the regulatory mechanism of m6A modification in dendritic cells to control anti-tumor immunity.
Bi YP, Yu LS, Deng QD, Kong LH, Guo FH, Zhang YC, Wang RX, Chen PR, Liu J, Fan XY. (2025) Photocatalytic labelling-enabled subcellular-resolved RNA profiling and synchronous multi-omics investigation. Nat. Chem., 17: 1871-1882.
Zhu XH, Chang ZH, Xiao WD, Zhang XB, Ma ML, Wu J, Hu JD, Bi Y, Kou XC, Zhao YH, Sheng YF, Dong BX, Sun JX, Chen C, Wu Y, Liu XL, Ding WQ, Jia KY, Yao YF, Sun LH, Yu XB, Wnag H, Liu J, Wnag YX, Gao SR, Gao YW. (2025) N6-methyladenosine on L1PA governs thetrans-silencing of LTRs and restrains totipotency in naïve human embryonic stem cells. Cell Stem Cell, 32: 1773-1791.
Yang L, Ma ML, Gao YW, Liu J. (2025) DecodingN6-methyladenosine's dynamic role in stem cell fate and early embryo development: insights into RNA-chromatin interactions. Curr. Opin. Genet. Dev., 91: 102311.
Xu MP, Liu XY, Wang M, Luo TT, Gao YW, Liu J, Shi JJ. (2025) BASAL: a universal mapping algorithm for nucleotide base-conversion sequencing. Nucleic Acids Res., 53: gkae1201.
Shi J, Pei XY, Peng JM, Wu CY, Lv YL, Wang XM, Zhou YZ, Yuan XT, Dong XB, Zhou S, Xu D, Zhao JL, Liu J, Huang J, Du B, Yao C, Zeng XF, Li MT, Chen HZ, Wang Qi. (2025) Monocyte-macrophage dynamics as key in disparate lung and peripheral immune responses in severe anti-melanoma differentiation-associated gene 5-positive dermatomyositis-related interstitial lung disease, Clin.Transl. Med., 15: e70226.
Kang ZH, Li RM, Liu C, Dong XZ, Hu YX, Xu L, Liu XY, Xiang YF, Gao LM, Si WZ, Wang L, Li Q, Zhang L, Wang H, Yang XR, Liu J. (2024) m6A-modified cenRNA stabilizes CENPA to ensure centromere integrity in cancer cells. Cell, 187: 6035-6054.
Dou XY, Huang LL, Xiao Y, Liu C, Li YN, Zhang XN, Yu LS, Zhao R, Yang L, Chen C, Yu XB, Gao BY, Qi MJ, Gao YW, Shen B, Sun SY, He C, Liu J. (2023) METTL14 is a chromatin regulator independent of its RNA N6-methyladenosine methyltransferase activity. Protein Cell, 14: 683-697.
Li YN, Dou XY, Liu J, Xiao Y, Zhang Z, Hayes L, Wu R, Fu XJ, Ye YZ, Yang B, Ostrow LW, He C, Sun SY. (2023) Globally reduced N6-methyladenosine (m6A) in C9ORF72-ALS/FTD dysregulates RNA metabolism and contributes to neurodegeneration. Nat. Neurosci., 26: 1328-1338.
Dou XY, Xiao Y, Shen C, Wang K, Wu T, Liu C, Li YN, Yu XB, Liu J, Dai Q, Pajdzik K, Ye C, Ge RQ, Gao BY, Yu JH, Sun SY, Chen MJ, Chen JJ, He C. (2023) RBFOX2 recognizes N6-methyladenosine to suppress transcription and block myeloid leukaemia differentiation. Nat. Cell Biol., 25: 1359-1368.
Zihong Kang, Weide Xiao, Lishan Yu, Xinyu Liu, Qidong Deng, Yifan Zhang, Xinning Zhang, Zhangxian Zhou, Li Tang, Yachao Bai, Kaiyuan Jia, Yihai Zhang, Bingyu Liang, Yunfan Xiang, Shiyao Zhu, Wenqing Ding
