Jun Liu, Ph.D.
RNA modification and ncRNA function
Assistant Professor, College of Life Sciences, Peking University
tel：
E-mail：junliu1223@pku.edu.cn
1. The new regulatory mechanism of RNA modifications on chromatin structure and gene transcription, and their related biological functions in stem cell fate determination, cell reprogramming, senescence and cancer.
2. The regulatory mechanism of functional non-coding RNA and related biological functions.
3. The regulatory mechanism of RNA modification/ncRNA on phase separation and the corresponding biological functions.
1. Demonstrated a new layer of chromatin state and transcription regulation by m6A-modified chromosome-associated RNA (carRNA).
2. Discovered the new regulatory mechanisms of how aberrant m6A methylation affecting cancer progression.
3. Discovered the regulatory mechanism of m6A modification in dendritic cells to control anti-tumor immunity.
Kang ZH, Li RM, Liu C, Dong XZ, Hu YX, Xu L, Liu XY, Xiang YF, Gao LM, Si WZ, Wang L, Li Q, Zhang L, Wang H, Yang XR, Liu J. (2024) m6A-modified cenRNA stabilizes CENPA to ensure centromere integrity in cancer cells. Cell, 187: 6035-6054.
Dou XY, Huang LL, Xiao Y, Liu C, Li YN, Zhang XN, Yu LS, Zhao R, Yang L, Chen C, Yu XB, Gao BY, Qi MJ, Gao YW, Shen B, Sun SY, He C, Liu J. (2023) METTL14 is a chromatin regulator independent of its RNA N6-methyladenosine methyltransferase activity. Protein Cell, 14: 683-697.
Li YN, Dou XY, Liu J, Xiao Y, Zhang Z, Hayes L, Wu R, Fu XJ, Ye YZ, Yang B, Ostrow LW, He C, Sun SY. (2023) Globally reduced N6-methyladenosine (m6A) in C9ORF72-ALS/FTD dysregulates RNA metabolism and contributes to neurodegeneration. Nat. Neurosci., 26: 1328-1338.
Dou XY, Xiao Y, Shen C, Wang K, Wu T, Liu C, Li YN, Yu XB, Liu J, Dai Q, Pajdzik K, Ye C, Ge RQ, Gao BY, Yu JH, Sun SY, Chen MJ, Chen JJ, He C. (2023) RBFOX2 recognizes N6-methyladenosine to suppress transcription and block myeloid leukaemia differentiation. Nat. Cell Biol., 25: 1359-1368.
Liu J, Dou X Y, Chen CY, Chen C, Liu C, Xu MM, Zhao SQ, Shen B, Gao YW, Han DL, He C. (2020) N6-methyladenosine of chromosome-associated regulatory RNA regulates chromatin state and transcription. Science, 367: 580-586.
Lulu Huang, Xiaoyang Liu, Zihong Kang, Tianyu Wang, Weide Xiao, Lishan Yu, Xinyu Liu, Qidong Deng, Yifan Zhang, Xinning Zhang, Zhangxian Zhou, Li Tang, Yachao Bai, Kaiyuan Jia
